Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Temporal changes in tectal cell surface specificity induced by nerve growth factor.

R Merrell, M W Pulliam, L Randono

    Proceedings of the National Academy of Sciences of the United States of America
    |November 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Twofold improved tumor-to-brain contrast using a novel T1 relaxation-enhanced steady-state (T<sub>1</sub>RESS) MRI technique.

    Science advances·2020
    Same author

    Dual β-Lactam Combinations Highly Active against Mycobacterium abscessus Complex <i>In Vitro</i>.

    mBio·2019
    Same author

    Symmetry breakdown of electron emission in extreme ultraviolet photoionization of argon.

    Nature communications·2018
    Same author

    Note: Soft X-ray transmission polarizer based on ferromagnetic thin films.

    The Review of scientific instruments·2018
    Same author

    A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients.

    Journal of neuro-oncology·2015
    Same author

    Single Shot Polarization Characterization of XUV FEL Pulses from Crossed Polarized Undulators.

    Scientific reports·2015

    Mouse submaxillary gland nerve growth factor induces changes in chick optic tectum cell adhesion. This effect differs from other tissues, suggesting nerve growth factor may mimic other specific trophic factors.

    Area of Science:

    • Developmental Neuroscience
    • Cell Biology
    • Molecular Biology

    Background:

    • Cell surface adhesive specificity changes during chick optic tectum development.
    • Nerve growth factor (NGF) is a key molecule in neural development.

    Purpose of the Study:

    • To investigate the role of mouse submaxillary gland nerve growth factor (NGF) in inducing changes in cell surface adhesive specificity in chick optic tectum.
    • To determine the specificity of NGF's action in this system and compare it to other neural tissues.

    Main Methods:

    • Utilizing rotating cultures of chick optic tectum cells.
    • Administering mouse submaxillary gland NGF and its derivatives (oxidized forms, insulin, proinsulin, dexamethasone) to the cultures.
    • Observing and quantifying changes in cell surface adhesive specificity.

    Related Experiment Videos

    Main Results:

    • Mouse submaxillary gland NGF (10(-7) M) successfully induced the developmental change in cell adhesive specificity in rotating tectal cell cultures.
    • Insulin, proinsulin, and dexamethasone did not affect adhesive specificity.
    • NGF modified by N-bromosuccinimide oxidation of tryptophan residues remained active, unlike in dorsal root or sympathetic ganglia studies.
    • Performic-acid-oxidized NGF was inactive.

    Conclusions:

    • Mouse submaxillary gland NGF can mimic the developmental changes in chick optic tectum cell adhesive specificity.
    • The specificity of NGF action in the optic tectum differs from that in dorsal root and sympathetic ganglia.
    • NGF may act as an analog for a structurally related trophic factor present at lower concentrations in the optic tectum.