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Chronic renal failure after Puumala virus infection
R Novo1, M F Gagnadoux, Y Le Guenno
1Service de Néphrologie Pédiatrique, Hôpital Necker Enfants Malades, F-75743 Paris Cedex 15, France.
Pediatric Nephrology (Berlin, Germany)
|December 22, 1999
Summary
Puumala hantavirus infection typically causes acute kidney injury with full recovery. This case study details a rare instance of persistent moderate renal impairment over two years post-infection in a young patient.
Area of Science:
- Nephrology
- Infectious Diseases
- Virology
Background:
- Puumala hantavirus infection is a significant cause of acute kidney injury.
- The infection is generally associated with complete renal function recovery.
Observation:
- A 15-year-old male presented with severe acute renal failure secondary to Puumala hantavirus infection.
- Despite initial improvement, renal function remained moderately impaired over two years post-infection.
Findings:
- This case represents the first documented instance of chronic renal failure following Puumala hantavirus infection.
- The patient exhibited a creatinine clearance of approximately 60 ml/min per 1.73 m(2) more than two years after the initial infection.
Implications:
- This finding challenges the established understanding of Puumala hantavirus's long-term renal effects.
- Further research is warranted to investigate the mechanisms and prevalence of persistent renal impairment after hantavirus infections.