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[Lamotrigine in the therapy of resistant epilepsy]
1Dipartimento di Scienze Neurologiche, Università degli Studi di Roma La Sapienza, Italia.
La Clinica Terapeutica
|December 22, 1999
Abstract
Objective:
To evaluate the efficacy of lamotrigine as single agent in patients with refractory epilepsy.
Materials And Methods:
Forty-seven adult patients with refractory epilepsy, in the initial phase received carbamazepine (1208 +/- 82.9 mg/day) plus lamotrigine (561.7 +/- 76.8 mg/day); during the second phase they received lamotrigine alone (206.4 +/- 44.4 mg/day).
Results:
Lamotrigine monotherapy significantly improved the number of seizures per week in comparison to lamotrigine combined with carbamazepine (p < 0.0001).
Conclusions:
Lamotrigine as single agent is more effective than carbamazepine + lamotrigine in patients with refractory epilepsy.