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Bone non-union after osteotomy in patients treated with methotrexate
J C Gerster1, R Bossy, J Dudler
1University Rheumatology and Rehabilitation Center, CHUV, Lausanne, Switzerland.
The Journal of Rheumatology
|December 22, 1999
Abstract:
We describe 2 men with seronegative rheumatoid arthritis who presented non-union of bone after osteotomy of the tibia in one case and of a metatarsal bone in the second. Both patients were still being treated with oral low doses of methotrexate (MTX). After MTX was stopped, a prompt healing of the bone occurred. These observations suggest that MTX should be stopped temporarily in cases with delayed bone healing after surgery.