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Human hypoxic ventilatory response with blood dopamine content under intermittent hypoxic training
T V Serebrovskaya1, I N Karaban, E E Kolesnikova
1AA Bogomoletz Institute of Physiology, Nacional Academy of Sciences of the Ukraine, Kiev. sereb@mail.kar.net
Canadian Journal of Physiology and Pharmacology
|December 22, 1999
Summary
Intermittent hypoxic training enhanced the hypoxic ventilatory response to severe hypoxia in healthy males. Blood dopamine and DOPA levels were associated with baseline ventilatory responses but did not correlate with training-induced changes.
Area of Science:
- Physiology
- Neuroscience
- Respiratory Medicine
Background:
- Intermittent hypoxia training (IHT) can improve hypoxic ventilatory response (HVR) in humans.
- Blood dopamine (DA) and its precursor DOPA may modulate respiratory responses to hypoxia.
Purpose of the Study:
- To investigate the relationship between blood dopamine and DOPA levels and HVR before and after IHT.
- To determine if IHT alters blood DA and DOPA concentrations and their correlation with HVR.
Main Methods:
- Eighteen healthy males underwent 2 weeks of IHT.
- HVR was measured using progressive hypoxic rebreathing.
- Blood samples were analyzed for DA and DOPA concentrations before and after IHT.
Main Results:
- Baseline high blood DA and DOPA correlated with lower HVR, higher tidal volume, and reduced respiratory frequency.
- IHT significantly increased HVR to severe hypoxia by 96% but not to mild hypoxia.
- No significant changes in blood DA were observed, but DOPA levels doubled; neither correlated with HVR changes post-training.
Conclusions:
- IHT effectively enhances HVR to severe hypoxia.
- Blood DA and DOPA levels influence baseline HVR, potentially via autoreceptor-mediated inhibition.
- The lack of correlation between DA/DOPA changes and HVR changes post-IHT suggests complex regulatory mechanisms.