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Adaptors for clathrin-mediated traffic.

T Kirchhausen1

  • 1Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. Kirchhausen@crystal.harvard.edu

Annual Review of Cell and Developmental Biology
|December 28, 1999
PubMed
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Clathrin adaptors are key proteins that link membrane proteins to clathrin coats, facilitating vesicular transport. This review explores recent advances in understanding how clathrin adaptors mediate cargo sorting for cellular trafficking.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Clathrin-mediated vesicular transport is crucial for cellular processes.
  • Clathrin coats, assembled from cytosolic clathrin, drive membrane deformation and vesicle formation.
  • Clathrin adaptors link membrane proteins to the clathrin coat, mediating cargo selection.

Purpose of the Study:

  • To review recent advances in the molecular mechanisms of cargo sorting by clathrin adaptors.
  • To highlight the role of clathrin adaptors in vesicular traffic from the plasma membrane and trans-Golgi network.

Main Methods:

  • Literature review of recent research on clathrin adaptors.
  • Analysis of molecular interactions between clathrin, adaptors, and cargo proteins.

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Main Results:

  • Clathrin adaptors play a pivotal role in recruiting specific cargo proteins to budding vesicles.
  • Understanding the molecular basis of adaptor function is essential for comprehending vesicular sorting.
  • Recent studies reveal intricate details of adaptor-mediated cargo recognition and linkage.

Conclusions:

  • Clathrin adaptors are central regulators of vesicular cargo sorting.
  • Further research into clathrin adaptor function will illuminate fundamental cellular trafficking pathways.
  • Advances in this area have significant implications for understanding diseases involving membrane trafficking defects.