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NAADP: An emerging calcium signaling molecule
1Department of Pharmacology, 6-120 Jackson Hall, 321 Church St. SE, University of Minnesota, Minneapolis, MN 55455, USA.
The Journal of Membrane Biology
|December 29, 1999
Summary
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered signaling molecule that mobilizes calcium ions (Ca2+) in cells. This research highlights its role alongside other calcium messengers.
Area of Science:
- Cellular Biology
- Biochemistry
- Physiology
Background:
- Cells utilize various calcium (Ca2+) stores and signaling molecules to regulate intracellular processes.
- Established Ca2+ messengers include inositol trisphosphate and cyclic ADP-ribose.
- The complexity of Ca2+ signaling pathways is increasingly recognized.
Purpose of the Study:
- To summarize recent findings on nicotinic acid adenine dinucleotide phosphate (NAADP) as a Ca2+ signaling molecule.
- To investigate the role of NAADP in both invertebrate and mammalian cells.
- To explore the implications of multiple Ca2+ messengers in cellular function.
Main Methods:
- Literature review of recent studies on NAADP.
- Analysis of experimental data demonstrating NAADP's Ca2+ mobilizing activity.
- Comparative analysis of Ca2+ signaling mechanisms across different cell types.
Main Results:
- Nicotinic acid adenine dinucleotide phosphate (NAADP) is identified as a potent Ca2+ signaling molecule.
- NAADP mobilizes Ca2+ in both invertebrate and mammalian cell systems.
- Evidence suggests a proliferation of Ca2+ messengers, including NAADP, in cellular signaling.
Conclusions:
- NAADP represents a significant addition to the known repertoire of Ca2+ signaling molecules.
- The discovery of NAADP expands our understanding of cellular calcium regulation.
- The existence of multiple Ca2+ messengers offers sophisticated control over cellular functions.