Related Experiment Video
Updated: Aug 18, 2026

Creation of Reversible Cholestatic Rat Model
Published on: May 21, 2011
[Management of cholestasis in pregnancy]
L Marpeau1, E Verspyck, G Descargues
1Hôpital Charles Nicolle, Rouer.
Diagnosis:
Pruritus in a pregnant women with healthy skin is suggestive of gravid cholestasis. The diagnosis can only be retained after ruling out viral or drug-induced hepatitis or gallbladder disease. The best markers are maternal serum transaminase and bile acid levels.
Fetal Risk:
The perinatal consequences of gravid cholestasis are minimal if reasonable premature delivery is accepted.
Therapeutic Options:
Ursodesoxycholic acid is an interesting therapeutic option if pruritus is untolerable or if the diagnosis is made early in pregnancy. Injection of vitamin K prevents coagulation disorders.
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