Related Experiment Videos
Respiratory failure attributable to moxidectin intoxication in a dog
M W Beal1, R H Poppenga, W J Birdsall
1Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA.
Journal of the American Veterinary Medical Association
|December 29, 1999
Summary
A Collie dog experienced severe toxicity, including coma and respiratory arrest, after ingesting moxidectin deworming medication. This case suggests Collies may have heightened susceptibility to high-dose moxidectin exposure.
Area of Science:
- Veterinary Toxicology
- Pharmacology
Background:
- Moxidectin is a widely used antiparasitic drug in veterinary medicine.
- Certain breeds, like Collies, are known to possess genetic mutations affecting drug metabolism and transport.
Observation:
- A 5-month-old Collie dog presented with severe neurological signs (coma, seizures, ataxia) and respiratory arrest post-ingestion of a moxidectin-containing dewormer.
- Moxidectin was confirmed in adipose tissue via liquid chromatography-mass spectrometry.
- The dog required intensive care, including mechanical ventilation and nutritional support.
Findings:
- The Collie dog recovered after 6 days of mechanical ventilation and was discharged on day 10.
- Clinical normalization was observed 24 days post-ingestion.
- Case data and manufacturer information suggest a potential increased susceptibility of Collies to high-dose moxidectin.
Implications:
- This case highlights the critical need for cautious moxidectin use in Collies, especially at higher dosages.
- Further research into P-glycoprotein function and moxidectin pharmacokinetics in Collies is warranted.
- Veterinarians should consider breed-specific sensitivities when prescribing moxidectin-based products.