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Combinatorial chemistry: polymer supported synthesis of peptide and non-peptide libraries
B Kundu1, S K Khare, S K Rastogi
1Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Abstract:
In recent years, combinatorial chemistry has emerged as a powerful tool for accelerating drug discovery. While industry is rapidly embracing the technology, researchers continue to develop novel library methods including resins, linkers, tagging and deconvolution techniques. Newer strategies involving computer-customized combinatorial libraries offer enormous potential for the design of more "focused" and "smart" chemical libraries with maximal diversity. In addition, miniaturized systems for synthesizing chemical libraries are also being developed, which has made it possible to carry out reactions at submicroliter volumes.