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Dietary effect on urinary thioethers
P B Rosen1, W R Snodgrass, M Riggs
1Department of Emergency Medicine, Scott & White Clinic and Memorial Hospital, Scott, Sherwood and Brindley Foundation, Texas A&M University Health Science Center, College of Medicine, Temple 76508, USA.
Archives of Environmental Health
|January 14, 2000
Summary
A diet low in thioethers significantly reduced urinary thioether excretion in most individuals. This finding helps establish baseline levels for reactive metabolite exposure assessment in non-exposed populations.
Area of Science:
- Biochemistry
- Toxicology
- Environmental Health
Background:
- Urinary thioethers serve as biomarkers for reactive metabolites.
- Glutathione is involved in detoxifying these reactive metabolites.
Purpose of the Study:
- To determine the effect of a controlled diet on urinary thioether levels.
- To establish a reference distribution curve for non-exposed populations.
Main Methods:
- Recruited office personnel screened for environmental exposures.
- Collected urine specimens before and after a low-thioether diet.
- Measured urinary thioethers using a modified Ellman technique.
Main Results:
- Dietary modification decreased thioether excretion in 75 of 126 subjects.
- Initial mean excretion difference was not statistically significant (p = .22).
- After removing outliers, a significant decrease in mean excretion was observed (p < .01).
Conclusions:
- A low-thioether diet effectively reduces urinary thioether excretion.
- This dietary intervention aids in establishing baseline biomarker levels.
- The study provides a reference for comparing thioether levels in exposed populations.