Related Experiment Video

Updated: Aug 10, 2026

Generation of Organotypic Raft Cultures from Primary Human Keratinocytes
07:26

Generation of Organotypic Raft Cultures from Primary Human Keratinocytes

Published on: February 22, 2012

Pathogenesis and treatment of juvenile onset recurrent respiratory papillomatosis

G E Green1, N M Bauman, R J Smith

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA.

Otolaryngologic Clinics of North America
|January 19, 2000
PubMed

Insights

Juvenile onset recurrent respiratory papillomatosis (JORRP), a common childhood laryngeal tumor caused by human papillomavirus, shows promise with new treatments. Research is exploring methods to reduce surgical complications and preventive strategies for JORRP.

Area of Science:

  • Pediatric Oncology
  • Virology
  • Laryngology

Background:

  • Juvenile onset recurrent respiratory papillomatosis (JORRP) is the most frequent laryngeal tumor in children.
  • JORRP is caused by the human papillomavirus (HPV).
  • The complete genetic structure of HPV is now understood.

Purpose of the Study:

  • To review current understanding and emerging treatments for JORRP.
  • To discuss strategies for reducing surgical morbidity associated with JORRP.
  • To evaluate the uncertain role of preventive measures in JORRP management.

Main Methods:

  • Review of preliminary studies on new therapeutic agents for JORRP.
  • Analysis of evolving methods aimed at minimizing surgical complications.
  • Assessment of the evidence regarding preventive interventions like elective Cesarean section.

Main Results:

  • New, targeted agents demonstrate potential for enhanced JORRP control in initial research.
  • There is growing awareness and investigation into techniques to decrease surgical morbidity.
  • The efficacy of preventive measures, including elective Cesarean section, remains inconclusive.

Conclusions:

  • Emerging therapies offer hope for improved management of JORRP.
  • Reducing surgical complications is a key focus in current JORRP care.
  • Further research is needed to clarify the role of preventive strategies in JORRP.

More Related Videos

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Local Hyperthermia for Warts Treatment04:25

Local Hyperthermia for Warts Treatment

Published on: November 8, 2024

Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...