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A cell-intrinsic timer that operates during oligodendrocyte development.

B Durand1, M Raff

  • 1Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA. bdurand@bcm.tmc.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 29, 2000
PubMed
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Oligodendrocyte precursor cells use an intrinsic timer to regulate their development. This timer, involving platelet-derived growth factor (PDGF) and thyroid hormone, controls cell division and differentiation.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Multicellular organism development follows a precise schedule.
  • Cellular development relies on intrinsic timers and external signals.
  • Oligodendrocytes, myelin-producing cells in the central nervous system, exemplify this interplay.

Purpose of the Study:

  • To investigate the intrinsic timing mechanisms governing oligodendrocyte precursor cell development.
  • To elucidate the roles of platelet-derived growth factor (PDGF) and thyroid hormone in cell cycle regulation and differentiation.

Main Methods:

  • Analysis of oligodendrocyte precursor cell proliferation and differentiation.
  • Investigation of the roles of PDGF and thyroid hormone in timing mechanisms.
  • Assessment of p27/Kip1 accumulation during cell cycle progression.

Related Experiment Videos

Main Results:

  • An intrinsic timing mechanism limits oligodendrocyte precursor cell division duration.
  • This mechanism comprises a timing component (PDGF-dependent) and an effector component (thyroid hormone-dependent).
  • The cell-cycle inhibitor p27/Kip1 is integral to both timer components.

Conclusions:

  • Oligodendrocyte differentiation is controlled by an intrinsic timer involving PDGF and thyroid hormone.
  • p27/Kip1 plays a crucial role in this timing mechanism.
  • Similar intrinsic timing mechanisms likely regulate development in other cell lineages.