Solid-Phase Synthesis of a Monofunctional trans-a(2)Pt(II) Complex Tethered to a Single-Stranded Oligonucleotide
Schmidt1, Filippov, Meeuwenoord
1Leiden Institute of Chemistry Gorlaeus Laboratories, Leiden University 2300 RA Leiden (The Netherlands).
Angewandte Chemie (International Ed. in English)
|January 29, 2000
Abstract:
Cross-linking ability is possible with the oligonucleotide-tethered, monofunctional trans-Pt(II) complex shown. It was synthesized by a novel solid-phase approach comprising conjugation of immobilized tetrathymidylic acid with a trans-a(2)Pt(II) building unit, ammonolysis, and transformation of the resulting complex (R=1-N-cyclohexylmethylthyminate) into the chloro derivative (R=Cl). a=NH(2)CH(3), T=thymine.
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