Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modulating chemokines: more lessons from viruses.

A S Lalani1, J W Barrett, G McFadden

  • 1Howard Hughes Medical Institute, Dept of Microbiology and Immunology, University of California San Francisco, 94143-0414, USA. lalani@itsa.ucsf.edu

Immunology Today
|February 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Head injury in older adults presenting to the ambulance service: who do we convey to the emergency department, and what clinical variables are associated with an intracranial bleed? A retrospective case-control study.

Scandinavian journal of trauma, resuscitation and emergency medicine·2023
Same author

Predictive clinical utility of pre-hospital point of care lactate for transfusion of blood product in patients with suspected traumatic haemorrhage: derivation of a decision-support tool.

Scandinavian journal of trauma, resuscitation and emergency medicine·2022
Same author

Establishment of four head and neck squamous cell carcinoma cell lines: importance of reference DNA for accurate genomic characterisation.

The Journal of laryngology and otology·2022
Same author

The prevalence of human papillomavirus in paediatric tonsils in Southwestern Ontario.

The Journal of laryngology and otology·2021
Same author

Helicopter emergency medical service dispatch in older trauma: time to reconsider the trigger?

Scandinavian journal of trauma, resuscitation and emergency medicine·2021
Same author

Combined Self-Collected Anterior Nasal and Oropharyngeal Specimens versus Provider-Collected Nasopharyngeal Swabs for the Detection of SARS-CoV-2.

Journal of clinical microbiology·2020
Same journal

Foreword.

Immunology today·2020
Same journal

The origin and significance of anti-DNA antibodies.

Immunology today·2014
Same journal

Mutations of class II MHC molecules.

Immunology today·2014
Same journal

Antigen processing at the molecular level.

Immunology today·2014
Same journal

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

Immunology today·2014
Same journal

Are MHC class II-restricted cytotoxic T lymphocytes important?

Immunology today·2014
See all related articles

Viruses manipulate host chemokines and their receptors to promote infection and evade immune responses. Understanding these viral strategies may lead to new treatments for viral diseases and inflammatory conditions.

Area of Science:

  • Immunology
  • Virology
  • Molecular Biology

Background:

  • Chemokines are key signaling molecules in the host inflammatory response to pathogens.
  • Viruses have evolved mechanisms to interfere with chemokine pathways for their own benefit.
  • Dysregulation of chemokines is implicated in various inflammatory disorders.

Purpose of the Study:

  • To explore the diverse strategies viruses employ to modulate host chemokines and their receptors.
  • To understand how viral manipulation of chemokines impacts host defense and viral propagation.
  • To identify potential therapeutic targets for viral infections and chemokine-related diseases.

Main Methods:

  • Literature review of viral-chemokine interactions.
  • Analysis of molecular mechanisms used by viruses to target chemokine signaling.

Related Experiment Videos

  • Examination of host immune evasion strategies involving chemokines.

    • Main Results:

    • Viruses utilize diverse tactics, including chemokine mimicry, receptor antagonism, and interference with chemokine production or signaling.
    • These viral strategies facilitate viral entry, replication, and dissemination by subverting immune cell trafficking and function.
    • Viral modulation of chemokines can exacerbate or dampen specific inflammatory responses.

    Conclusions:

    • Viral manipulation of the chemokine system is a critical factor in host-pathogen interactions.
    • Elucidating these viral strategies offers insights into novel therapeutic interventions for viral diseases.
    • Targeting chemokine pathways presents a promising avenue for managing inflammatory disorders.