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Updated: Jun 29, 2026

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis
Published on: October 30, 2014
Molecular motors: the driving force behind mammalian left-right development
D M Supp1, S S Potter, M Brueckner
1Research Dept, Shriners Hospital for Children, Cincinnati, OH 45229, USA.
Abstract:
The molecular motors dynein and kinesin are large protein complexes that convert the energy generated by ATP hydrolysis into directional movement along the microtubule cytoskeleton. They are required for a myriad of cellular processes, including mitotic spindle movement, axonal and vesicular transport, and ciliary beating. Recently, it has been shown that, in addition, they have a unique role during embryonic patterning: they are required to orient and establish the left-right axis in early vertebrate development.
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