Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional and compositional changes in pulmonary surfactant in response to exercise.

K E Morrison1, R F Slocombe, S A McKane

  • 1School of Veterinary Science, University of Melbourne, Veterinary Clinical Centre, Werribee, Victoria, Australia.

Equine Veterinary Journal. Supplement
|February 5, 2000
PubMed
Summary

Intense exercise in horses can decrease pulmonary surfactant function, potentially causing exercise-induced pulmonary hemorrhage. Individual horses show varying surfactant activity, which may indicate a risk factor.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of 'gastrostomy tube - is it for me?', a web-based patient decision aid for people living with motor neurone disease considering having a gastrostomy tube placed.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2023
Same author

The effect of automated oxygen control on clinical outcomes in preterm infants: a pre- and post-implementation cohort study.

European journal of pediatrics·2021
Same author

Brexanolone for the treatment of patients with postpartum depression.

Drugs of today (Barcelona, Spain : 1998)·2019
Same author

Sudden death of a crossbred calf associated with a myocardial adenomatoid tumour.

Australian veterinary journal·2018
Same author

Prevalence and risk factors for medical events following exercise at Australian Greyhound race meetings.

Australian veterinary journal·2018
Same author

Metastatic mineralisation caused by vitamin D intoxication in hand-raised short-beaked echidnas (Tachyglossus aculeatus).

Australian veterinary journal·2017

Area of Science:

  • Equine respiratory physiology
  • Pulmonary surfactant research
  • Exercise-induced pulmonary hemorrhage

Background:

  • Pulmonary surfactant plays a crucial role in lung function by reducing surface tension.
  • Exercise-induced pulmonary hemorrhage (EIPH) is a common condition in athletic horses.
  • Understanding surfactant function in relation to exercise is vital for equine health.

Purpose of the Study:

  • To investigate the impact of an incremental-intensity treadmill exercise program on pulmonary surfactant function in horses.
  • To determine if exercise affects surfactant phospholipid content and functional activity.
  • To explore the relationship between individual surfactant characteristics and EIPH risk.

Main Methods:

  • Collected bronchoalveolar lavage fluid from control and exercised horses over six weeks.

Related Experiment Videos

  • Assessed phospholipid content via phosphorus assay and surfactant activity using bubble surfactometry.
  • Adjusted cell counts for alveolar epithelial lining fluid (ELF) dilution using the lavage/serum urea ratio.

    • Main Results:

    • Exercise led to increased nucleated cells (macrophages) and erythrocytes in ELF, indicating intrapulmonary hemorrhage.
    • Surface tension significantly increased in the exercised group, while surfactant phospholipid content remained unchanged.
    • Surfactant functional activity varied significantly between individual horses, independent of phospholipid levels.

    Conclusions:

    • High-intensity exercise causing intrapulmonary hemorrhage impairs pulmonary surfactant function without altering phospholipid content.
    • Individual variations in surfactant function may represent a risk factor for developing EIPH in horses.
    • Further research into these functional differences is warranted to understand EIPH pathogenesis.