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1Alpha-hydroxyvitamin D3 prevents the decrease of bone mineral density in lactating beagles.

F Ichikawa1, K Katagiri, Y Higuchi

  • 1Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd., Shizuoka, Japan.

The Journal of Veterinary Medical Science
|February 17, 2000
PubMed
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Lactating beagles experienced significant bone mineral density loss, particularly in vertebrae. Supplementation with 1alpha-hydroxyvitamin D3 (1alpha(OH)D3) effectively prevented this bone density decrease without adverse effects.

Area of Science:

  • Veterinary Medicine
  • Bone Physiology
  • Pharmacology

Background:

  • Bone mineral density (BMD) changes during lactation are critical in female mammals.
  • Dual energy X-ray absorptiometry (DXA) offers high precision for assessing BMD in beagles.

Purpose of the Study:

  • To evaluate BMD changes in lactating beagles using DXA.
  • To investigate the preventive efficacy of 1alpha-hydroxyvitamin D3 (1alpha(OH)D3) against lactation-induced BMD loss.

Main Methods:

  • Lactating beagles (2-5 years old) were monitored for BMD changes using DXA.
  • A control group and a group receiving 1alpha(OH)D3 (0.1 microg/kg, 3x/week) were compared.
  • Vertebral (L2-L4) and tibial BMD were assessed over time.

Main Results:

Related Experiment Videos

  • A significant decrease in vertebral BMD was observed in the control group during lactation.
  • 1alpha(OH)D3 supplementation suppressed vertebral BMD loss during lactation.
  • 1alpha(OH)D3 also showed a preventive effect on tibial BMD decrease.
  • No adverse effects like hypercalcemia or hypercalciuria were noted.

Conclusions:

  • DXA is a reliable method for detecting BMD changes in lactating beagles, especially in trabecular-rich lumbar vertebrae.
  • 1alpha(OH)D3 effectively prevents bone mineral density reduction during lactation in beagles.
  • 1alpha(OH)D3 shows promise as a safe supplement for maintaining bone health in lactating dogs.