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Inhibition of myocardial inward rectifier potassium current by propylbutyldopamine
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|May 8, 2000
Abstract
Aim:
To study the effects of propylbutyldopamine (PBDA) on the inward rectifier potassium current (Ik1).
Methods:
The quasi-steady state current-voltage relationship from the isolated guinea pig ventricular cells were measured using whole-cell patch-clamp techniques with a slow ramp depolarization (8 mV.s-1).
Results:
PBDA 5, 50, and 100 mumol.L-1 concentration-dependently reduced the inward rectifier potassium current. PBDA blocked Ik1 in guinea pig ventricular cells. The effect of PBDA was not blocked by the selective dopamine D2-receptor blocker, domperidone.
Conclusion:
PBDA inhibited Ik1 directly, independent of the dopamine D2-receptor.