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Theophylline improves acute mountain sickness.

R Fischer1, S M Lang, U Steiner

  • 1Dept of Medicine, Klinikum Innenstadt, University of Munich, Germany.

The European Respiratory Journal
|March 4, 2000
PubMed
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Theophylline effectively reduces symptoms of acute mountain sickness (AMS) during rapid high-altitude ascents. This study demonstrates theophylline

Area of Science:

  • Altitude Medicine
  • Pharmacology
  • Respiratory Physiology

Background:

  • Acute mountain sickness (AMS) is a common condition during rapid ascent to high altitudes.
  • Effective pharmacological interventions for AMS are limited, necessitating further research.

Purpose of the Study:

  • To evaluate the efficacy of oral slow-release theophylline in preventing and treating acute mountain sickness.
  • To assess the impact of theophylline on physiological parameters during simulated and natural high-altitude exposure.

Main Methods:

  • A two-part randomized, single-blind, placebo-controlled study was conducted.
  • Participants received either slow-release theophylline or placebo twice daily before and during altitude exposure (simulated 4,500 m and natural 3,454 m).
  • Acute mountain sickness scores (AMSS), respiratory rate, pulse, oxygen saturation, and arterial blood gases were monitored.

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Main Results:

  • Theophylline significantly reduced AMSS in both the simulated and natural high-altitude studies (p=0.03).
  • Subjects receiving theophylline exhibited lower AMSS compared to placebo groups.
  • Improved oxygenation was observed in both study arms with theophylline administration.

Conclusions:

  • Oral slow-release theophylline is an effective treatment for acute mountain sickness.
  • Theophylline demonstrates potential as a prophylactic and therapeutic agent for high-altitude exposure.