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From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility
1Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Imlanier@mit.edu
Current Opinion in Neurobiology
|February 19, 2000
Abstract:
The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins. These findings suggest that Abl and its associated proteins may regulate cell adhesion and actin polymerization, thereby regulating growth cone motility during axonogenesis.