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Cutaneous hypersensitivity reaction to injectable hyaluronic acid gel
1Washington Institute of Dermatologic Laser Surgery, Washington, D.C. 20037, USA.
Background:
Injectable hyaluronic acid gel is a non-animal biomaterial used for soft tissue augmentation.
Objective:
The dermal implantation of this naturally occurring polysaccharide is reported to be well tolerated by patients, with a longer duration in tissue than bovine collagen without any major local or systemic side effects. We report a case of an acute hypersensitivity reaction in a woman after her third injection for improvement of melolabial fold wrinkles.
Methods:
An adverse granulomatous-like response to the intradermal injection of a modified hyaluronic acid gel is described.
Results:
The patient developed indurated and erythematous papulocystic nodules in the melolabial folds bilaterally at the sites of injection.
Conclusion:
Injectable hyaluronic acid gel can be associated with severe allergic reactions and patients should be warned of this possible treatment side effect.