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Mechanistic studies of multipole storage assisted dissociation
K Håkansson1, J Axelsson, M Palmblad
1Ion Physics Division, Angström Laboratory, Uppsala University, Sweden. kristina.hakansson@angstrom.uu.se
Journal of the American Society for Mass Spectrometry
|March 4, 2000
Summary
Hexapole charge density critically influences fragmentation in multipole storage assisted dissociation (MSAD). Higher densities increase ion oscillation amplitudes, leading to dissociation via collisions with residual gas molecules.
Area of Science:
- Analytical Chemistry
- Physical Chemistry
- Mass Spectrometry
Background:
- Multipole storage assisted dissociation (MSAD) is a technique used in mass spectrometry.
- Understanding fragmentation mechanisms is crucial for optimizing dissociation techniques.
Purpose of the Study:
- To investigate the factors affecting fragmentation in MSAD.
- To elucidate the mechanism of MSAD by studying hexapole parameters.
Main Methods:
- Investigated MSAD fragmentation degree and onset.
- Varied hexapole charge density and storage time using a pulsed shutter.
- Performed simulations of ion trajectories within the hexapole.
Main Results:
- Hexapole charge density was identified as the most critical parameter for MSAD.
- Dependencies on storage time, radio-frequency (rf) amplitude, and pressure were observed.
- MSAD and sustained off-resonance irradiation (SORI) spectra showed similar appearances.
Conclusions:
- Proposed a dissociation mechanism for MSAD involving increased ion radial oscillation at higher charge densities.
- This mechanism leads to elevated kinetic energies and subsequent dissociation through collisions.
- The findings provide insights into optimizing MSAD for analytical applications.