Related Experiment Videos
Metabolic influences in experimental thrombosis.
Annals of the New York Academy of Sciences
|January 1, 1976
Summary
Metabolic factors significantly impact blood clotting and thrombosis. Nutritional and endocrine states influence susceptibility, but can be reversed with specific treatments like glucose or insulin.
Area of Science:
- Biochemistry
- Physiology
- Pathology
Background:
- Intravascular coagulation and thrombosis are complex processes.
- Noncoagulation factors, including metabolic, endocrinologic, and nutritional states, can influence these processes.
Purpose of the Study:
- To investigate the influence of metabolic and nutritional states on blood coagulation and thrombosis.
- To determine the role of free fatty acids in thrombosis susceptibility.
Main Methods:
- Administration of a human serum procoagulant fraction to rats in various metabolic states (fed, fasted, diabetic, obese).
- Assessment of clotting abnormalities, thrombosis, and hemorrhage.
- Measurement of serum free fatty acid concentrations.
- Infusion of free fatty acid-albumin preparations in normal rats.
Main Results:
- Fasted, diabetic, and obese rats exhibited hypercoagulability, thrombosis, and hemorrhage when injected with the procoagulant fraction, unlike normal fed rats.
- Glucose injection reversed thrombosis susceptibility in fasted rats; insulin injection reversed it in diabetic rats.
- Elevated serum free fatty acids were observed in susceptible animals and normalized after glucose/insulin treatment in fasted/diabetic rats.
- Infusion of free fatty acids rendered normal rats susceptible to thrombosis.
Conclusions:
- Metabolic, nutritional, and endocrinologic states significantly influence intravascular coagulation and thrombosis.
- Free fatty acids play a crucial role in mediating thrombosis susceptibility in altered metabolic conditions.