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Importance of a pyrogallol-type structure in catechin compounds for apoptosis-inducing activity
K Saeki1, S Hayakawa, M Isemura
1School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Phytochemistry
|March 7, 2000
Abstract:
Several catechin compounds were examined for their ability to induce apoptosis in human histiocytic lymphoma U937 cells. Catechins with a pyrogallol-type structure in a B-ring induced apoptosis and a 3-O-gallate group in cis-relationship to the B ring enhanced the activity. Catechins without a pyrogallol-type structure in a molecule lacked activity. These data suggest the important role of the 5'(3')-hydroxyl group in the B-ring and that a pyrogallol-type structure in a molecule is a minimum requirement for apoptosis induction by catechin compounds.