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Increased nitric oxide production in the spermatic vein of patients with varicocele
E Ozbek1, Y Turkoz, R Gokdeniz
1Department of Urology, Inonu University School of Medicine, Malatya, Turkey.
Objective:
To define the level of nitric oxide (NO) in the spermatic vein of patients with varicocele and its relation with male infertility.
Materials And Methods:
Following physical and color Doppler ultrasonographic examination, whole blood samples were drawn from a peripheral vein and a dilated varicocele vein from fourteen patients with clinically palpable varicocele (G2-3) before ligation. NO levels in the serum were determined as total nitrite by Greiss reaction and results were compared with Mann-Whitney U test.
Results:
NO levels in the internal spermatic vein were 36.05 +/- 8. 92 micromol/l, compared to 19.41 +/- 4.12 micromol/l in the peripheral vein and the difference was statistically significant (p < 0.01).
Conclusion:
In view of our results, increased NO levels in the dilated varicocele vein might be responsible for spermatozoa dysfunction.
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