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Fluorescence in situ hybridization: molecular probes for diagnosis of pediatric neoplastic diseases

S C Raimondi1

  • 1Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. susana.raimondi@stjude.org

Cancer Investigation
|March 8, 2000
PubMed

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In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
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