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Oxidant damage during and after spaceflight.

T P Stein1, M J Leskiw

  • 1Department of Surgery, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, New Jersey 08084, USA. tpstein@umdnj.edu

American Journal of Physiology. Endocrinology and Metabolism
|March 11, 2000
PubMed
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Spaceflight decreases oxidative damage during missions, but increases it upon return. This study measured markers of oxidative stress in astronauts and found significant changes post-flight.

Area of Science:

  • Space medicine
  • Biomedical research
  • Oxidative stress

Background:

  • Spaceflight poses unique physiological challenges.
  • Understanding oxidative damage is crucial for astronaut health.
  • Bed rest models simulate some spaceflight effects.

Purpose of the Study:

  • Assess oxidative damage during and after spaceflight.
  • Compare spaceflight oxidative damage to bed rest.
  • Investigate markers of lipid and DNA damage.

Main Methods:

  • Measured urinary 8-iso-prostaglandin F(2alpha) and 8-oxo-7,8-dihydro-2 deoxyguanosine.
  • Collected samples before, during, and after long-duration (MIR) and short-duration (shuttle) spaceflight.
  • Included a 17-day head-down tilt bed rest study for comparison.
Keywords:
NASA Discipline Regulatory PhysiologyNASA Experiment Number 9401613NASA Program Biomedical Research and CountermeasuresNon-NASA Center

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Main Results:

  • In-flight, 8-iso-PGF(2alpha) decreased on MIR and shuttle, attributed to reduced energy intake.
  • Post-flight, both 8-iso-PGF(2alpha) and 8-OH DG increased significantly.
  • Bed rest showed no changes in-flight, but an increase in 8-iso-PGF(2alpha) during recovery.

Conclusions:

  • Oxidative damage is reduced during spaceflight.
  • Oxidative damage increases after spaceflight due to metabolic shifts and reduced antioxidant defenses.
  • Findings highlight the need for countermeasures against post-flight oxidative stress.