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Synthesis and antibacterial activity of 2alpha-functionalized 1beta-methylcarbapenems related to KR-21012
1Korea Research Institute of Chemical Technology, Yusung, Taejon, South Korea.
Bioorganic & Medicinal Chemistry Letters
|March 14, 2000
Abstract:
The 2alpha-functionalized 1beta-methylcarbapenems 3 were synthesized from the 2-formyl 1beta-methylcarbapenem intermediate 5. The best compound in the series of 2alpha-(hydroxy)alkylcarbapenems, KR-21012, displayed well balanced in vitro and in vivo activity as a parent compound of oral carbapenem.