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Updated: Aug 14, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
[Myelogenous system cells' activity in the bone marrow in children with acute leukemia remission]
J Rybczyńska1, B Sikorska-Fic, M Wasik
1Zakładu Diagnostyki Laboratoryjnej i Immunologii Klinicznej Wieku Rozwojowego Akademii Medycznej w Warszawie.
Abstract:
Myelogenic system cells' activity was evaluated in 12 bone marrow samples taken from the children in acute leukemia's remission period and 7 samples from the patients in whom malignant disease of the hematopoietic system was ruled out. Cell activity was evaluated with the nFMLP induced chemiluminiscence test (CL) in the luminol environment. In the bone marrow of the patients in the period of acute leukemia remission the cells' chemiluminiscence was, considerably higher than in the control material. It appears that in the acute leukemia's remission period a functional regeneration of the myeloid line cells occurs.
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