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Updated: Aug 9, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Pathogenesis of adrenocortical incidentalomas and genetic syndromes associated with adrenocortical neoplasms
C Gicquel1, J Bertherat, Y Le Bouc
1Laboratoire d'Explorations Fonctionnelles Endocriniennes, Hôpital Trousseau, Paris, France.
Abstract:
The study of genetic syndromes associated with adrenocortical tumors (Beckwith-Wiedemann, Li-Fraumeni, McCune-Albright, Carney, and multiple endocrine neoplasia type 1) has shed light on the molecular basis of tumorigenesis. Abnormalities at the 11p15 locus appear as crucial and frequent events found specifically in malignant, sporadic tumors, leading to overexpression of a growth-promoting factor and loss of expression of tumor suppressor genes. In benign tumors, the cAMP pathway can be exacerbated in an ACTH-independent manner when various membrane receptors of the seven transmembrane superfamily are "illegitimately" expressed.
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