Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary ciliary dyskinesia (PCD).

M Meeks1, A Bush

  • 1Rayne Institute, Royal Free and University College Medical School, University College London, London, UK.

Pediatric Pulmonology
|March 29, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subthalamic nucleus neurons encode syllable sequence and phonetic characteristics during speech.

Journal of neurophysiology·2024
Same author

The new biologic drugs: Which children with asthma should get what?

Pediatric pulmonology·2024
Same author

Replicate DNA metabarcoding can discriminate seasonal and spatial abundance shifts in river macroinvertebrate assemblages.

Molecular ecology resources·2023
Same author

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis.

Allergy·2023
Same author

Alpha1-antitrypsin deficiency in Greece: Focus on rare variants.

Pulmonology·2023
Same author

Early Pseudomonas aeruginosa predicts poorer pulmonary function in preschool children with cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2022
Same journal

Safety of Less Invasive Surfactant Administration in Preterm Infants: A Meta-Analysis.

Pediatric pulmonology·2026
Same journal

Early Oxygenation Trajectory and Noninvasive Ventilation Failure in Non-Immunocompromised Children With Pediatric ARDS.

Pediatric pulmonology·2026
Same journal

Pulmonary Exacerbations and Treatment in PCD: A Narrative Review.

Pediatric pulmonology·2026
Same journal

Asthma in Children With Congenital Lung Malformations: A Population-Based Case-Control Study.

Pediatric pulmonology·2026
Same journal

Long-Term Effect Of COVID-19 on Children's Lung Function: A Prospective Longitudinal Study.

Pediatric pulmonology·2026
Same journal

Administrative Prevalence and Healthcare Utilization of Pediatric Cystic Fibrosis in a Middle-Income Country: A 10-Year Analysis of National Administrative Data.

Pediatric pulmonology·2026
See all related articles

Primary ciliary dyskinesia (PCD) is a rare genetic disorder affecting cilia function, leading to significant illness. Early diagnosis and proper management of PCD are crucial for reducing patient morbidity.

Area of Science:

  • Medical Genetics
  • Cell Biology
  • Respiratory Medicine

Background:

  • Primary ciliary dyskinesia (PCD) is a rare genetic disorder affecting cilia, complex organelles vital for respiratory and reproductive functions.
  • Cilia dysfunction in PCD leads to impaired mucociliary clearance and associated morbidity, despite its low prevalence (1 in 20,000).
  • Understanding ciliary function and mucociliary clearance is key to addressing PCD-related health issues.

Purpose of the Study:

  • To summarize current scientific and clinical knowledge on primary ciliary dyskinesia (PCD).
  • To discuss the relationship between ciliary function, mucociliary clearance, and laterality defects.
  • To review human clinical aspects and emerging developments in PCD research and management.

Main Methods:

Related Experiment Videos

  • Literature review of scientific and clinical knowledge on PCD.
  • Summary of research on ciliary function and mucociliary clearance.
  • Discussion of animal models exhibiting PCD phenotypes and human clinical data.

    • Main Results:

    • PCD is a rare but morbid condition impacting respiratory and reproductive health.
    • Cilia are complex organelles with critical roles, and their dysfunction underlies PCD.
    • Laterality defects are associated with ciliary dysfunction.

    Conclusions:

    • Accurate diagnosis and management of PCD can significantly reduce morbidity.
    • Continued research into ciliary function and PCD pathogenesis is essential for improving patient outcomes.
    • New developments offer promise for future investigation and treatment of PCD.