Related Experiment Video

Updated: Aug 13, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

Level of left ventricular dysfunction in endomyocardial biopsy-proven myocarditis

D Zivkov-Saponja1, A Stojsić-Milosavljević, D Stojsić

  • 1Klinika za kardiologiju, Institut za kardiovaskularne bolesti, Sremska Kamenica.

Medicinski Pregled
|April 5, 2000
PubMed

Insights

Myocarditis significantly impairs heart function, leading to heart failure. Hemodynamic parameters like ejection fraction (EF) and end-diastolic pressure reveal systolic and diastolic dysfunction in active myocarditis patients.

Area of Science:

  • Cardiology
  • Pathophysiology
  • Medical Diagnostics

Background:

  • Myocarditis is linked to heart failure, but the extent of myocardial functional impairment is debated.
  • Previous studies suggest global chronic or acute heart failure development in myocarditis patients.

Purpose of the Study:

  • To identify hemodynamic parameters that describe myocardial systolic and diastolic impairment levels in myocarditis.
  • To correlate hemodynamic findings with myocarditis severity based on Dallas Criteria.

Main Methods:

  • Investigated 95 myocarditis patients and 36 controls using right and left heart catheterization.
  • Performed endomyocardial biopsy (EMB) on a subset of patients.
  • Classified patients into active myocarditis with fibrosis, active myocarditis without fibrosis, and borderline myocarditis groups.

Main Results:

  • Left ventricle ejection fraction (EF), indicating systolic function, differed significantly from controls.
  • Cardiac index showed no significant difference between patient and control groups.
  • Elevated left ventricle end-diastolic pressure, signifying diastolic dysfunction, was observed in active myocarditis but not borderline cases.

Conclusions:

  • Hemodynamic assessment, particularly EF and end-diastolic pressure, can effectively describe systolic and diastolic myocardial impairment in myocarditis.
  • Active myocarditis is associated with both systolic and diastolic dysfunction, while borderline cases may show preserved diastolic function.

More Related Videos

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...