Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hematologic management of gastrointestinal bleeding.

G S Maltz1, J E Siegel, J L Carson

  • 1Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, USA.

Gastroenterology Clinics of North America
|February 7, 2001
PubMed
Summary

Managing gastrointestinal (GI) bleeding requires assessing causes and coagulation issues. Evidence is limited on optimal erythrocyte transfusion triggers and platelet counts for patients with GI bleeding.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase I, randomized, double-blind, placebo-controlled, single-dose escalation study of the recombinant factor VIIa variant BAY 86-6150 in hemophilia.

Journal of thrombosis and haemostasis : JTH·2012
Same author

Transfusion triggers: state of the art in 2010.

Acta anaesthesiologica Belgica·2011
Same author

Ultrastructural characterization of epithelial cell membranes in normal human conducting airway epithelium: A freeze-fracture study.

The American journal of anatomy·2010
Same author

Physicochemical basis for dilated intercellular spaces in non-erosive acid-damaged rabbit esophageal epithelium.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2008
Same author

Selenium deficiency alters epithelial cell morphology and responses to influenza.

Free radical biology & medicine·2007
Same author

Health and health care status of African-born residents of Metropolitan Washington, DC.

Journal of immigrant health·2005

Area of Science:

  • Hematology
  • Gastroenterology
  • Internal Medicine

Background:

  • Gastrointestinal (GI) bleeding necessitates comprehensive hematologic management.
  • Key considerations include identifying bleeding causes, exacerbating conditions, and coagulation abnormalities.

Purpose of the Study:

  • To review the current understanding and evidence gaps in the hematologic management of GI bleeding.
  • To highlight uncertainties regarding erythrocyte transfusion thresholds and platelet count indications.
  • To discuss the coagulopathy of liver disease and fresh-frozen plasma (FFP) administration in GI bleeding.

Main Methods:

  • Literature review and synthesis of existing evidence.
  • Analysis of current practices in erythrocyte, platelet, and fresh-frozen plasma transfusion.

Related Experiment Videos

  • Identification of areas lacking robust clinical trial data.

    • Main Results:

    • Limited data exists on specific anemia levels dictating erythrocyte transfusion risk in GI bleeding.
    • Evidence is scarce regarding the degree of thrombocytopenia associated with increased bleeding risk.
    • The coagulopathy of liver disease is common; standard fresh-frozen plasma (FFP) dosing (2 units) is often insufficient.

    Conclusions:

    • Optimal transfusion strategies for GI bleeding require further research.
    • Current practices for platelet and FFP administration may not be evidence-based or sufficient.
    • Standardized guidelines are needed for hematologic management of GI bleeding to improve patient outcomes.