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Updated: Aug 5, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
Non-Severe Clostridium difficile Infection
Kazi I Ullah1, Olga C Aroniadis2
1Department of Gastroenterology, Stony Brook University Hospital, Stony Brook, NY, USA.
Abstract:
Clostridium difficile infection (CDI) is classified as non-severe, severe, or fulminant based on clinical severity and presence of complications. Clinical manifestations span a broad spectrum, ranging from mild self-limited diarrhea to severe colonic inflammation with potentially fatal outcomes. Management strategies for CDI are guided by this severity-based classification. In this article, the authors focus on non-severe CDI, reviewing its definition, diagnostic approach, prevention strategies, treatment options, and predictors of treatment failure. They conclude by highlighting emerging areas of research and future directions in the management of non-severe CDI.
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