Related Experiment Video

Updated: Oct 17, 2026

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
15:16

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

[Rotavirus diarrhea. Impact in a pediatric hospital of Buenos Aires]

F S González1, M E Sordo, G Rowensztein

  • 1Laboratorio de Virología, Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires.

Medicina
|February 7, 2001
PubMed

Insights

Rotavirus diarrhea significantly impacts children under three, causing 36-45% of cases in outpatient and hospitalized settings. The rotavirus vaccine, administered at 2, 4, and 6 months, could prevent the majority of these preventable diarrheal diseases.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Public health

Context:

  • Rotavirus is a leading cause of severe diarrheal disease in infants and young children globally.
  • The study was conducted in anticipation of the rotavirus vaccine's introduction.
  • Understanding the local disease burden is crucial for vaccine impact assessment.

Purpose:

  • To estimate the burden of rotavirus-associated diarrhea in a pediatric hospital setting.
  • To identify the age groups and seasonality of rotavirus disease.
  • To inform the potential impact of rotavirus vaccination.

Summary:

  • A study of 648 children under three years old found rotavirus in 36% of outpatient and 45% of hospitalized diarrhea cases.
  • An estimated 1674 rotavirus diarrheal episodes occur annually in outpatient clinics, with a small proportion requiring hospitalization.
  • Rotavirus cases peaked between March and June, predominantly affecting children aged 6 to 23 months.

Impact:

  • The findings highlight the significant burden of rotavirus disease in young children.
  • The study underscores the potential of the rotavirus vaccine to prevent a substantial number of severe diarrhea cases.
  • Results provide valuable data for public health strategies and vaccine program evaluation.

More Related Videos

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...