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[Ethanol inhibits platelet monoamine oxidase type B activity in patients with alcoholism]
E M Krupitskiĭ1, G F Karandashova, V V Vostrikov
1Regional Scientific Center for Research in Addictions and Psychopharmacology, Pavlov St. Petersburg State Medical University. kru@lond.spb.su
Voprosy Meditsinskoi Khimii
|April 13, 2000
Abstract:
The influence of 400 mM ethanol on the activity of monoamine oxidase type B (MAO-B) of blood platelets has been studied in vitro in 30 alcoholic patients and 30 healthy volunteers. Benzylamine was used as a substrate for MAO-B. MAO-B inhibition by ethanol was higher in alcoholics compared to healthy volunteers. The higher vulnerability of MAO-B of alcoholics inhibiting action to of ethanol may be one of the mechanisms underlying some symptoms of alcoholism.