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Related Experiment Videos

["Adenoid" glioblastoma].

M Shintaku1, S Nakatsu, S Okamoto

  • 1Department of Pathology, Osaka Red Cross Hospital, Japan.

No Shinkei Geka. Neurological Surgery
|April 19, 2000
PubMed
Summary

This case report details a rare glioblastoma with an adenoid appearance in an 81-year-old woman. Despite treatment, the patient succumbed to the aggressive brain tumor 21 months post-diagnosis.

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Area of Science:

  • Neuro-oncology
  • Surgical Pathology
  • Neurosurgery

Background:

  • Glioblastoma is an aggressive primary brain tumor.
  • Unusual histopathological variants can mimic metastatic disease.
  • Early diagnosis and treatment are crucial for patient outcomes.

Observation:

  • An 81-year-old woman presented with gait instability.
  • Neuroradiology identified three distinct brain lesions.
  • Histopathology revealed glioblastoma with a central "adenoid" or "epithelioid" pattern.

Findings:

  • The tumor exhibited typical glioblastoma features peripherally.
  • Centrally, tumor cells formed papillary and solid nests resembling adenocarcinoma.
  • Immunohistochemistry and ultrastructural studies ruled out epithelial differentiation.

Implications:

  • This case underscores the importance of considering rare glioblastoma morphologies.
  • Accurate histopathological and immunohistochemical analysis is crucial for diagnosis.
  • Aggressive treatment strategies may be necessary for such variants.

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