Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cholesterol embolism--a serious systemic disease].

E Palmgren1, M Hartford, H Herlitz

  • 1Njurmedicinska avdelningen, Universitetssjukhuset, Sahlgrenska, Göteborg.

Lakartidningen
|April 20, 2000
PubMed
Summary

Cholesterol embolism syndrome, a severe condition affecting multiple organs, particularly the kidneys, has a high mortality rate. Early diagnosis and prophylaxis in patients with atherosclerosis undergoing vascular procedures are crucial due to the lack of effective treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High platelet count is associated with low bone mineral density: The MrOS Sweden cohort.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

A retrospective study investigating the impact of radical radiotherapy on the nutritional status of patients with lung cancer.

Clinical nutrition ESPEN·2017
Same author

Pharmacodynamic effects of the oral glucokinase activator AZD6370 after single doses in healthy volunteers assessed with euglycaemic clamp.

Diabetes, obesity & metabolism·2012
Same author

Oxidative stress and endothelin-1 in atherosclerotic renal artery stenosis and effects of renal angioplasty.

Kidney & blood pressure research·2011
Same author

Community-based gender perspectives of triage and treatment in suspected myocardial infarction.

International journal of cardiology·2010
Same author

C-reactive protein, interleukin-6, secretory phospholipase A2 group IIA and intercellular adhesion molecule-1 in the prediction of late outcome events after acute coronary syndromes.

Journal of internal medicine·2007

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Pathology

Background:

  • Cholesterol embolism syndrome (CES) is a serious multiorgan disorder resulting from cholesterol crystal emboli originating from atherosclerotic plaques.
  • The kidneys are most frequently affected (approximately 50% of cases), often leading to progressive renal failure.
  • CES carries a poor prognosis, with a mortality rate around 70%.

Observation:

  • This report details two of four CES cases diagnosed in elderly men with advanced atherosclerosis during autumn 1997.
  • Diagnosis was confirmed by identifying cholesterol crystals in renal arteries via biopsy.
  • Patients presented with progressive renal failure, initially suspected as vasculitis or radiologically induced renal damage.

Findings:

  • Renal biopsy did not reveal vasculitis in any patient initially.

Related Experiment Videos

  • One patient, initially ANCA positive, later developed vasculitis.
  • Three out of four patients died within two months; one patient with renal vasculitis survived for 1.5 years after treatment with cyclophosphamide and steroids.

    • Implications:

    • CES should be strongly considered in elderly patients with atherosclerosis presenting with progressive renal and multi-organ failure.
    • Invasive vascular procedures like angiography and surgery increase the risk of CES.
    • Prophylaxis, including identifying at-risk patients before procedures, is paramount as no effective therapy currently exists.