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Amplification of the c-myc oncogene in non-small cell lung cancer
H A Ozkara1, S Ozkara, S Topçu
1Department of Biochemistry, Hacettepe University, Faculty of Medicine, Ankara, Turkey. ozkara@ato.org.tr
Abstract:
Fresh non-small cell lung carcinoma surgical specimens were taken from 17 patients and 3 controls and screened for genetic abnormalities of the c-myc oncogene. Southern blot hybridization analysis demonstrated two- to fivefold amplification of the c-myc gene in 10 cases, i.e., 7 of 13 epidermoid lung carcinomas, 2 of 3 adenocarcinomas and 1 of 1 osteogenic sarcoma metastatic to the lung. Two- to fivefold amplification was observed in tissues from stage III and IV epidermoid carcinomas and adenocarcinomas of the lung. A correlation between cancer stage and c-myc gene amplification was found.
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