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Cytokine therapeutics for infectious diseases
F H Rodriguez1, S Nelson, J K Kolls
1Department of Biology, Christian Brothers University, Memphis, TN, USA.
Current Pharmaceutical Design
|May 2, 2000
Summary
Cytokines, immune response modifiers, are explored as adjuvants for treating infections, including drug-resistant cases. This review covers protein and gene therapies enhancing immune responses against pathogens.
Area of Science:
- Immunology
- Infectious Diseases
- Pharmacology
Background:
- Cytokines are crucial signaling molecules regulating innate and adaptive immunity.
- The clinical application of cytokines has expanded, particularly for augmenting immune responses.
- Recent research investigates cytokines for infections, even in immunocompetent individuals.
Purpose of the Study:
- To review the use of cytokines as adjuvants in treating infectious diseases.
- To explore both protein-based and gene-based cytokine therapies.
- To assess the potential of cytokines against significant and drug-resistant infections.
Main Methods:
- Literature review of cytokine applications in infectious disease treatment.
- Analysis of studies using cytokines as adjunct therapy.
- Examination of protein and gene-based therapeutic strategies.
Main Results:
- Cytokines show promise in supporting immune responses during infections.
- Therapeutic applications are being developed for various infectious agents.
- Both protein and gene delivery methods are under investigation.
Conclusions:
- Cytokines represent a valuable therapeutic avenue for infectious diseases.
- Their role as adjuvants, particularly for resistant infections, warrants further study.
- Future research should focus on optimizing cytokine-based immunotherapies.