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Related Experiment Videos

Interventions for treating gonorrhoea in pregnancy.

P Brocklehurst1

  • 1National Perinatal Epidemiology Unit, Institute of Health Sciences, Old Road, Headington, Oxford, UK, OX3 7LF. peter.brocklehurst@perinat.ox.ac.uk

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary

This review found that amoxicillin, spectinomycin, and ceftriaxone are effective antibiotic treatments for pregnant women with gonorrhea. These treatments ensure microbiological cure and are suitable for those with penicillin allergies.

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Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Neonatal Health

Background:

  • Neisseria gonorrhoeae poses a risk of transmission from mother to newborn during birth, potentially causing gonococcal ophthalmia neonatorum.
  • Genital gonorrhea infections during pregnancy require effective treatment to prevent adverse neonatal and maternal outcomes.

Purpose of the Study:

  • To evaluate the efficacy of different antibiotic regimens for treating genital gonorrhea in pregnant women.
  • To assess the impact of these treatments on both neonatal and maternal morbidity.

Main Methods:

  • Systematic review of randomized controlled trials comparing antibiotic regimens for genital gonorrhea in pregnant women.
  • Searches conducted in the Cochrane Pregnancy and Childbirth Group trials register and Cochrane Controlled Trials Register up to October 1998.

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Main Results:

  • Two trials with 329 women were included in the analysis.
  • Amoxicillin with probenicid, spectinomycin, and ceftriaxone demonstrated comparable microbiological cure rates, defined by negative gonococcal cultures.

Conclusions:

  • All evaluated antibiotic regimens are effective for treating gonorrhea in pregnancy, achieving microbiological cure.
  • Ceftriaxone and spectinomycin offer effective alternatives for pregnant individuals with penicillin allergies, ensuring comparable cure rates.