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Review: perinucleolar structures.

S Huang1

  • 1Department of Cell and Molecular Biology, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois, 60611, USA.

Journal of Structural Biology
|May 12, 2000
PubMed
Summary
This summary is machine-generated.

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This review covers the perinucleolar compartment (PNC) and Sam68 nuclear body (SNB), highlighting their shared RNA-binding protein enrichment and nucleolar localization. Their functions remain elusive, despite observed prevalence in transformed cells.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Recent research has identified several novel perinucleolar structures.
  • The perinucleolar compartment (PNC) and Sam68 nuclear body (SNB) are two such structures with distinct characteristics.

Purpose of the Study:

  • To review and summarize recent findings on the ultrastructure and molecular composition of PNCs and SNBs.
  • To discuss shared features and differences between these perinucleolar structures.
  • To introduce a third perinucleolar structure identified by hnRNP L labeling.

Main Methods:

  • Literature review of recent studies on PNCs and SNBs.
  • Analysis of ultrastructural and molecular component data.
  • Comparison of localization and cellular prevalence.

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Main Results:

  • PNCs and SNBs share enrichment in RNA-binding proteins and nucleic acids.
  • Both structures are primarily located at the nucleolus periphery.
  • They are frequently observed in transformed cells, with prevalence varying by cell type.
  • Structural integrity is linked to the cell's transcriptional state.

Conclusions:

  • The precise functions of PNCs and SNBs are currently unknown.
  • Further research is needed to elucidate the roles of these perinucleolar structures in cellular processes.
  • Understanding these structures may offer insights into cell transformation and regulation.