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Antimitotic diterpenes from Erythropodium caribaeorum test pharmacophore models for microtubule stabilization
B Cinel1, M Roberge, H Behrisch
1Department of Chemistry, University of British Columbia, Vancouver, Canada.
Organic Letters
|May 18, 2000
Abstract:
[structure: see text] Six new antimitotic diterpenes, 2-7, have been isolated from the Caribbean octocoral Erythropodium caribaeorum. Structural variations encountered in this group of natural products test recently proposed pharmacophore models for microtubule stabilizing compounds.