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Poly(ADP-ribose) polymerase in DNA damage-response pathway: implications for radiation oncology

V A Soldatenkov1, M Smulson

  • 1Department of Radiation Medicine, Georgetown University School of Medicine, Washington, District of Columbia, USA. soldates@gunet.georgetown.edu

International Journal of Cancer
|May 18, 2000
PubMed
Summary

Poly(ADP-ribose) polymerase (PARP) is crucial for DNA repair and programmed cell death. Targeting PARP may sensitize tumor cells to genotoxic agents and radiotherapy.

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