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Related Experiment Videos

Group A streptococcal throat colonization is a dynamic phenomenon.

K P Dawson1, H Nsanze, A S Ameen

  • 1Department of Paediatrics, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates. KDawson@uaeu.ac.ae

Annals of Tropical Paediatrics
|May 29, 2000
PubMed
Summary

Group A Streptococcus (GAS) throat colonization in children is a dynamic process. Asymptomatic children often show fluctuating GAS strains over weeks, indicating a complex colonization pattern.

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Area of Science:

  • Microbiology
  • Pediatric Infectious Diseases
  • Epidemiology

Background:

  • Group A Streptococcus (GAS) is a common bacterial pathogen.
  • Understanding asymptomatic colonization is crucial for infection control.
  • Previous studies have not fully elucidated the dynamic nature of GAS colonization in children.

Purpose of the Study:

  • To investigate the nature of group A streptococcal throat colonization in asymptomatic children.
  • To characterize the serotype dynamics of GAS during colonization.
  • To determine the duration and pattern of GAS carriage in a pediatric cohort.

Main Methods:

  • A cohort of healthy, asymptomatic children was prospectively studied.
  • Throat swabs were collected weekly for 5 weeks for GAS antigen detection and culture.

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  • GAS isolates were serotyped for T antigen to identify different strains.

    • Main Results:

    • Twenty-two children were identified with GAS colonization.
    • 50% of colonized children had positive antigen tests and cultures at least five times over the 6-week study period.
    • No consistent T-antigen type pattern was observed; individuals frequently harbored multiple T-types and non-typeable strains, which alternated over time.

    Conclusions:

    • Throat colonization by group A Streptococcus is a dynamic process in children.
    • Colonization involves a fluctuating presence of multiple GAS serotypes.
    • The waxing and waning of different strains suggest a complex ecological interaction within the nasopharynx.