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Evolution of DNA and RNA as catalysts for chemical reactions
1Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Institute of Chemistry, Berlin, D-14195, Germany. jaschke@chemie.fu-berlin.de
Current Opinion in Chemical Biology
|May 29, 2000
Abstract:
In vitro selection from combinatorial nucleic acid libraries has provided new RNA and DNA molecules that have catalytic properties. Catalyzed reactions now go far beyond self-modifying reactions of nucleic acid molecules. The future application of in vitro selected RNA and DNA catalysts in bioorganic synthesis appears promising.