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Cyclodextrins in transdermal and rectal delivery.

Matsuda1, Arima

  • 1Nihon Shokuhin Kako Co., 30Tajima, Fuji, Shizuoka, 417-8530, Japan

Advanced Drug Delivery Reviews
|June 6, 2000
PubMed
Summary

Cyclodextrins (CDs) and their derivatives enhance transdermal and rectal drug delivery for systemic and local effects. Their application in cosmetics is also advancing, offering new delivery possibilities.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Transdermal and rectal drug routes supplement oral delivery for targeted systemic or local effects.
  • Cyclodextrins (CDs) and their derivatives are explored for enhancing drug permeation.
  • The use of CDs in dermal and rectal delivery, as well as cosmetics, is expanding.

Purpose of the Study:

  • To review the current applications of parent CDs and CD derivatives in transdermal and rectal drug delivery.
  • To evaluate the efficacy of CDs in delivering low molecular weight agents via these routes.
  • To highlight the progress of hydrophilic CD derivatives in cosmetic applications.

Main Methods:

  • Literature review of in-vitro and in-vivo studies on CD-mediated transdermal and rectal drug delivery.
  • Analysis of studies focusing on parent CDs and chemically modified CD derivatives.
  • Examination of research on hydrophilic CD derivatives in cosmetic formulations.

Main Results:

  • Parent CDs and CD derivatives show significant potential in improving transdermal and rectal drug delivery.
  • CDs facilitate the delivery of conventional low molecular weight drugs through skin and rectal mucosa.
  • Hydrophilic CD derivatives are increasingly utilized in cosmetic products for enhanced efficacy and stability.

Conclusions:

  • Cyclodextrins and their derivatives are valuable excipients for optimizing transdermal and rectal drug delivery systems.
  • Further research into CD applications can lead to improved therapeutic outcomes and novel cosmetic formulations.
  • The versatility of CDs supports their role in both pharmaceutical and cosmetic industries.

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