Coordination of metabolic activity and stress resistance in yeast longevity

The genetic analysis of longevity in yeast has revealed the importance of metabolic control and resistance to stress in aging. It has also shown that these two physiological processes are interwoven. Molecular mechanisms underlying the longevity effects of metabolic control and stress resistance, as well as genetic stability, are emerging. The yeast RAS genes play a substantial role in coordinating at least the first two of these processes. Numerous correlates can be found between the physiological processes involved in yeast aging and aging in Caenorhabditis elegans and in Drosophila, and the dietary restriction paradigm in mammals.