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Single-molecule studies of DNA mechanics
C Bustamante1, S B Smith, J Liphardt
1Department of Molecular and Cell Biology, Department of Physics, University of California, Berkeley, CA 94720, USA. carlos@alice. berkeley.edu.
Current Opinion in Structural Biology
|June 14, 2000
Abstract:
During the past decade, physical techniques such as optical tweezers and atomic force microscopy were used to study the mechanical properties of DNA at the single-molecule level. Knowledge of DNA's stretching and twisting properties now permits these single-molecule techniques to be used in the study of biological processes such as DNA replication and transcription.